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| Sosa, Silvio; Pelin, Marco; Cavion, Federica; Herve, Fabienne; Hess, Philipp; Tubaro, Aurelia. |
| Pinnatoxin G (PnTx-G) is a marine cyclic imine toxin produced by the dinoflagellate Vulcanodinium rugosum, frequently detected in edible shellfish from Ingril Lagoon (France). As other pinnatoxins, to date, no human poisonings ascribed to consumption of PnTx-G contaminated seafood have been reported, despite its potent antagonism at nicotinic acetylcholine receptors and its high and fast-acting toxicity after intraperitoneal or oral administration in mice. The hazard characterization of PnTx-G by oral exposure is limited to a single acute toxicity study recording lethality and clinical signs in non-fasted mice treated by gavage or through voluntary food ingestion, which showed differences in PnTx-G toxic potency. Thus, an acute toxicity study was carried... |
| Tipo: Text |
Palavras-chave: Vulcanodinium rugosum; Pinnatoxin G; Dinoflagellates; Harmful algae; Oral toxicity. |
| Ano: 2020 |
URL: https://archimer.ifremer.fr/doc/00605/71724/70190.pdf |
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